Fig. 1

NORAD was highly expressed in OSCC cells and boosted OSCC progression. a NORAD expression was examined in OSCC tissue and adjacent normal tissue by RT-qPCR assay. b NORAD expression was tested in OSCC cell lines (HSC-4, UM1, HSC-3 and SCC-15) and normal keratinocyte (NOK) by RT-qPCR assay. c RT-qPCR assay was conducted to detect the expression of NORAD in HSC-4 and UM1 cell transfected with sh-NORAD#1/#2. d–f The ability of cell proliferation upon NORAD silencing was detected by CCK-8, colony formation and EdU assays. g The apoptosis rate of cells upon NORAD silencing was assessed by flow cytometry analysis. h The relevant protein level of apoptosis in cells transfected with sh-NORAD#1/#2 was analyzed by western blot. i Cell migration upon NORAD silencing was estimated by Transwell assays. j Western blot assay was applied to measure the protein level of EMT-associated proteins in cells transfected with sh-NORAD#1/#2. **P < 0.01