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Table 5 Top ten most significant miRNA, their cancer-type sign and prognosis factor according to the literature

From: Common pathways and functional profiles reveal underlying patterns in Breast, Kidney and Lung cancers

Significant miRNA BRCA KIRC LUAD Function Prognosis Factor
mir-21 UP UP UP Oncogene,
Targets tumor inhibitor proteins (LZTFL1)
Promotes proliferation and metastases [31, 32], UP: related to poor prognosis
mir-96 UP DOWN UP Oncogene, MEK/ERK signaling by targeting AKR (BRCA) Invasion, metastasis progression [33, 34], UP: poor prognosis
mir-139 DOWN DOWN DOWN Tumor suppressor Suppress proliferation, tumor growth and metastasis [35, 36], UP:better prognosis
mir-141 UP DOWN UP Oncogene Promotes proliferation and inhibits tumor cell apoptosis [37, 38], UP: poor prognosis
mir-183 UP DOWN UP Oncogene Cell viability, proliferation, invasion and metastasis [33, 39], UP: poor prognosis
mir-184 UP DOWN DOWN Suppressor gene Proliferation, invasion, apoptosis, [40]
UP: better prognosis (BRCA),
DOWN: better prognosis (KIRC)
mir-200 DOWN DOWN DOWN Suppressor gene, TRAIL pathway, VEGF and VEGFR signaling network and epithelial-mesenchymal transition Cancer invasion and metastasis, Level variation may correlate with disease progression [41],
DOWN: better prognosis
mir-206 DOWN DOWN DOWN Oncogene (BRCA), Tumor suppressor (LUAD, KIRC) Cell invasion, migration, proliferation,
Prognosis depend on cancer type [42,43,44]
mir-210 UP UP UP Oncogene (BRCA, LUAD), Suppressor gene (KIRC) Treatment resistance (tamoxifen) [45]
UP: poor prognosis (BRCA, LUAD) and good prognosis (KIRC)
mir-584 UP DOWN DOWN Tumor suppressor UP: better prognosis (BRCA)
DOWN: worse prognosis (KIRC) and better prognosis (LUAD) [46, 47]