Table 5 Top ten most significant miRNA, their cancer-type sign and prognosis factor according to the literature
Significant miRNA | BRCA | KIRC | LUAD | Function | Prognosis Factor |
|---|---|---|---|---|---|
mir-21 | UP | UP | UP | Oncogene, Targets tumor inhibitor proteins (LZTFL1) | Promotes proliferation and metastases [31, 32], UP: related to poor prognosis |
mir-96 | UP | DOWN | UP | Oncogene, MEK/ERK signaling by targeting AKR (BRCA) | Invasion, metastasis progression [33, 34], UP: poor prognosis |
mir-139 | DOWN | DOWN | DOWN | Tumor suppressor | Suppress proliferation, tumor growth and metastasis [35, 36], UP:better prognosis |
mir-141 | UP | DOWN | UP | Oncogene | Promotes proliferation and inhibits tumor cell apoptosis [37, 38], UP: poor prognosis |
mir-183 | UP | DOWN | UP | Oncogene | Cell viability, proliferation, invasion and metastasis [33, 39], UP: poor prognosis |
mir-184 | UP | DOWN | DOWN | Suppressor gene | Proliferation, invasion, apoptosis, [40] UP: better prognosis (BRCA), DOWN: better prognosis (KIRC) |
mir-200 | DOWN | DOWN | DOWN | Suppressor gene, TRAIL pathway, VEGF and VEGFR signaling network and epithelial-mesenchymal transition | Cancer invasion and metastasis, Level variation may correlate with disease progression [41], DOWN: better prognosis |
mir-206 | DOWN | DOWN | DOWN | Oncogene (BRCA), Tumor suppressor (LUAD, KIRC) | Cell invasion, migration, proliferation, |
mir-210 | UP | UP | UP | Oncogene (BRCA, LUAD), Suppressor gene (KIRC) | Treatment resistance (tamoxifen) [45] UP: poor prognosis (BRCA, LUAD) and good prognosis (KIRC) |
mir-584 | UP | DOWN | DOWN | Tumor suppressor | UP: better prognosis (BRCA) DOWN: worse prognosis (KIRC) and better prognosis (LUAD) [46, 47] |