Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site

Table 2 Number of experimentally proven zinc ions per protein molecule located in structures used in the phylogenetic tree analysis in this study

PDB ID	UniProt ID	Annotation	Organism	Number of bound Zn ions	Ref.
1AMP	Q01693	Leucyl aminopeptidase	Vibrio proteolyticus (Vp)	2	[28]
1TKJ	P80561	Aminopeptidase	Streptomyces griseus (Sg)	2	n/a
1Z8L	Q04609	Carboxypeptidase	Homo sapiens (Hs)	2	[59]
2AFO	Q16769	Cyclotransferase	Homo sapiens (Hs)	1	[60]
3FEC	Q9Y3Q0	Carboxypeptidase	Homo sapiens (Hs)	2	[61]
3GUX	A6KZZ2	Leucine aminopeptidase	Bacteroides vulgatus (Bv)	1	n/a
3IIB	A1S420	Aminopeptidase	Shewanella amazonensis (Sa)	2	n/a
3 PB4	Q9NXS2	Cyclotransferase	Homo sapiens (Hs)	1	[62]
3SI1	Q9CYK2	Cyclotransferase	Mus musculus (Mm)	1	[63]
3TC8	A6LHT4	Leucine aminopeptidase	Parabacteroides distasonis (Pd)	1	n/a
4F9U	Q9VRQ9	Cyclotransferase	Drosophila melanogaster (Dm)	1	[30]
4FAI	Q86PD7	Isoglutaminyl cyclase	Drosophila melanogaster (Dm)	1	[30]
4FUU	Q8A4P9	Leucine aminopeptidase	Bacteroides thetaiotaomicron (Bt)	1	n/a
4MHN	B7QK46	Cyclotransferase	Ixodes scapularis (Is)	1	n/a
4TWE	Q9UQQ1	Aminopeptidase	Homo sapiens (Hs)	2	[64]
5GNE	Q5ZZH8	Leucine aminopeptidase	Legionella pneumophila (Lp)	2	[65]
5IB9	A2V759	Aminopeptidase	Aneurinibacillus sp. AM-1 (Ab)	2	n/a
6ESL	Q5ZRR6	Aminopeptidase	Legionella pneumophila (Lp)	2	[66]
6HC6	P25152	Aminopeptidase	Bacillus subtilis (Bs)	2	n/a
6QQL	Q7MT37	Glutamine cyclotransferase-related protein	Porphyromonas gingivalis (Pg)	1	n/a

This table lists all the PDB structure codes with annotations, literature references (n/a - not applicable if none is available) and number of Zinc ions bound per protein molecule

ISSN: 1745-6150