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Table 1 A summary of some of the key hallmarks that distinguish archaeal, bacterial and eukaryotic cells. Further details are presented in the text

From: Division of labour in a matrix, rather than phagocytosis or endosymbiosis, as a route for the origin of eukaryotic cells

Property

Archaea

Bacteria

Eukarya

Typical Size (diameter)

0.5-4 μm

0.5-4 μm

1.0-100 μm

Chromosome(s) and mRNA

Circular, compact, with polycistronic operons.

Circular, compact, with polycistronic operons.

Linear chromosomes, genes with introns, long intergenic sequences. Monocistronic transcripts, complex spliceosome, mRNA poly A tail. Nucleolus.

Internal structure

No membrane-enveloped organelles. No nucleus.

No membrane-enveloped organelles. No nucleus.

Membrane-enveloped organelles, mitochondria and nucleus.

Cytoarchitecture

simple

simple

complex

ATP-generation

Chemiosmosis across the cell membrane

Chemiosmosis across the cell membrane

Chemiosmosis across the mitochondrial membrane.

Membrane lipids

• Glycerol-ether lipids.

sn-glycerol-1-phosphate backbone.

• Isoprenoid side chains.

• Glycerol-ester lipids.

sn-glycerol-3-phosphate backbone.

• Fatty acid side chains.

• Glycerol-ester lipids.

sn-glycerol-3-phosphate backbone.

• Fatty acid side chains.