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Fig. 2 | Biology Direct

Fig. 2

From: Model-based exploration of the impact of glucose metabolism on the estrous cycle dynamics in dairy cows

Fig. 2

Schematic representation of the coupled metabolic-reproductive model. The coupled model links the metabolic model (right hand side) to the bovine estrous cycle model [26] (left hand side). Red arrows depict the sites where both models are coupled. Insulin acts on the site of anterior pituitary influencing LH and FSH release to the blood circulation. Insulin stimulates IGF-1 levels in the blood. Progesterone inhibits IGF-1 secretion which in turn decreases the responsiveness of follicular cells to LH

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