Fig. 2

Snapshots of simulations plotted by Repast. a-c The same simulation is shown at three different times. a The inset shows an early endosome (blue perimeter), carrying Tf (red) and dextran (green) cargoes (red + green = yellow content), and also a soluble (S) and a membrane (M) markers. Nearby another early endosome containing just Tf (red content) is present. b After fusion and fission, the membrane marker is segregated to an endosome containing mostly Tf, and the soluble marker to an early endosome containing mostly dextran (inset). c Finally, the endosome containing the soluble marker (S) and dextran matured to a RabD structure (red perimeter) containing an internal vesicle (“1” character). The endosome carrying the membrane marker (M), after fusion and fission is now a RabB endosome (cyan perimeter) containing Tf (inset). d A larger world of 9 × 9 μm with much more organelles. e A reduced world of 2.25 X 2.25 μm. f A rectangular world of 2.25 X 4.5 μm. The blue bar at the upper left corner of the worlds corresponds to 0.5 μm