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Fig. 2 | Biology Direct

Fig. 2

From: Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome

Fig. 2

JACK-STAT signaling pathway with the circuit ending in MYC protein. That triggers response to DNA damage. Significantly (FDR-adj. p-value = 1.94 × 10− 32) deactivated in patients with MYCN amplification. The results and the representation have been obtained with the program HiPathia [5]. Blue and red nodes indicate genes downregulated and upregulated, respectively, in patients with MYCN amplification. The deactivations of nodes that transmit the signal concomitantly with the activation of signal repressor genes strongly suggest the actuation of a regulatory program to inhibit the signal

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Biology Direct

ISSN: 1745-6150

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