Fig. 1

Phylogenetic reconstruction of Tim17 protein family. A tree of 5588 amino acid sequences returned by HHsearch in the Uniprot database of reference proteomes constructed using FastTree. The alignment of 136 positions was used for the reconstruction. The affiliation of protein sequences to particular supergroups of eukaryotes was color-coded. In the case of Tmem135 proteins, which contain two linked Tim17 domains, these domains were analyzed separately as N-terminal (N) and C-terminal (C) parts. Coloured triangles depict related N- and C-terminal Tim17 domains of Tmem135 proteins