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Table 1 Model parameters for colon/intestinal crypts

From: The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts

Parameter Estimated value Ref. Simulations
n: height of human colon crypt (number of cells in one column of crypt) 80 [53] varied (2–80)
n: height of murine intestinal crypt (number of cells in one column of crypt) 25 [33]  
σ: probability of symmetric division 16 % in epidermis, [4] varied (0–1)
  50 % for intestine, 100 % in germline cells [5, 6]  
u: mutation rate 10−7 in normal cells to 10−2 in the case of chromosomal instability [68] u 1 varied from 0.0005 to 0.01
    u 2 varied from 0.0001 to 0.02