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Fig. 3 | Biology Direct

Fig. 3

From: Primary and metastatic tumor dormancy as a result of population heterogeneity

Fig. 3

Parametrically heterogeneous logistic growth model with respect to growth rate parameter c. Parameter of truncated exponential distribution on the interval c [0, 1] is taken to be μ = 120, initial population size is N(0) = 0.001, K = 1. As can be seen, (a) in this case population escapes dormancy at t ≈ 120 months = 10 years. b The escape phase is accompanied by rapid increase in the expected value of c, as well as (c) a rapid increase in variance, which remains at a non-zero value even when the population is at a steady state. d The distribution of clones over time also changes away from the initial composition, albeit less dramatically than in the parametrically heterogeneous Malthusian model

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