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Table 2 Twenty-seven main cancer types. Cancer types are shown with the corresponding tissue/organ of occurrence and number of local somatic mutations and originating samples in COSMIC

From: Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development

Tissue/organ

Cancer types

Number of local somatic mutations in COSMIC

Number of samples

Average number of mutations per sample

Bladder

Bladder cancer

6 265

3 027

2.07

Blood

Acute myeloid leukemia

11 650

5 857

1.99

Chronic myeloid leukemia

1 603

1 041

1.54

Lymphoma

24 572

6 944

3.54

Bone

Bone cancer

2 814

706

3.99

Brain

Glioblastoma

9 361

2 909

3.22

Neuroblastoma

4 932

619

7.97

Glioma

12 793

2 947

4.34

Medulloblastoma

4 701

728

6.46

Breast

Breast cancer

31 544

4 404

7.16

Cervix

Cervical cancer

136

132

1.03

Colorectal

Colorectal cancer

37 727

25 806

1.46

Esophagus

Esophageal cancer

3 659

433

8.45

Head and neck

Thyroid cancer

19 975

13 908

1.44

Head and neck carcinoma

75

67

1.12

Kidney

Renal cell carcinoma

27 897

1 750

15.94

Liver

Hepatocellular carcinoma

19 100

2 091

9.13

Lung

Small cell lung cancer

976

208

4.69

Non-small cell lung cancer

19 991

11 236

1.78

Ovary

Ovarian cancer

19 286

2 936

6.57

Pancreas

Pancreatic cancer

33 776

5 609

6.02

Prostate

Prostate cancer

18 813

967

19.46

Skin

Melanoma

12 374

7 923

1.56

Squamous cell carcinoma

15 726

3 459

4.55

Basal cell carcinoma

292

251

1.16

Stomach

Stomach cancer

7 795

1 430

5.45

Uterus

Endometrial cancer

5 722

1 627

3.52

Total

353 555

109 015

3.24