Fig. 7

Domain architecture of sequence examples HEM1_METKA, TIP12_MAIZE and Q9K8K1_BACHD. The sequences were analyzed by the Pfam webserver (http://pfam.xfam.org/). Briefly, HEM1_METKA has three domains: GlutR_N (PF05201.10) with E-value of 3.1e–39 from positions 7–142, Shikimate_DH (PF01488.15) with E-value of 2.4e–38 from positions 156–292 and GlutR_dimer (PF00745.15) with E-value of 1.2e–13 from positions 305–403 (See Fig. 7a). In the case of TIP12_MAIZE, it has a single domain hit to MIP (PF00230.15) with E-value of 1.1e–75 from positions 13–234 (See Fig. 7b). Lastly, the sequence Q9K8K1_BACHD has a single domain hit to an unknown domain DUF819 (PF05684) with E-value of 4.1e–155 from positions 10–388 (See Fig. 7c). Generally speaking, there is no way to assert if the significance of these domain hits are mainly attributed to the fold-critical sequence segments of the sequence-to-domain alignments. In the case of Q9K8K1_BACHD, the hit to an unknown domain offers little information pertaining to its plausible biological function