Table 5 Summary of FBA results
Human | Yeast | Reaction tested | Yeast 7.0 results | |
|---|---|---|---|---|
Knock-out growth | Explanation | |||
P13716 | P05373 | Porphobilinogen synthesis | No FBA growth | Ferroheme b + Yeast 7.0 biomass equation |
P22830 | P16622 | Protoheme ferrochelatase | No FBA growth | Ferroheme b + Yeast 7.0 biomass equation |
P48637 | Q08220 | Glutathione synthesis | WT growth (μ = 0.1405 hr−1) | 0 flux through reaction in WT (r_0485) |
P49247 | Q12189 | Ribose-5-phosphate isomerization | No FBA growth | Phosphoribosyl-pyrophosphate block |
Q96GX9 | P47095 | Methylthioribulose 1-phosphate dehydratase | Not determined | Gene not present in Yeast 7.0 model |
Q9Y2Z4 | P48527 | Mitochondrial tyrosine-tRNA-ligase reaction | No FBA growth | Mitochondrial tRNA requirement + Yeast 7.0 biomass equation |