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Table 5 Summary of FBA results

From: A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

Human Yeast Reaction tested Yeast 7.0 results
Knock-out growth Explanation
P13716 P05373 Porphobilinogen synthesis No FBA growth Ferroheme b + Yeast 7.0 biomass equation
P22830 P16622 Protoheme ferrochelatase No FBA growth Ferroheme b + Yeast 7.0 biomass equation
P48637 Q08220 Glutathione synthesis WT growth (μ = 0.1405 hr−1) 0 flux through reaction in WT (r_0485)
P49247 Q12189 Ribose-5-phosphate isomerization No FBA growth Phosphoribosyl-pyrophosphate block
Q96GX9 P47095 Methylthioribulose 1-phosphate dehydratase Not determined Gene not present in Yeast 7.0 model
Q9Y2Z4 P48527 Mitochondrial tyrosine-tRNA-ligase reaction No FBA growth Mitochondrial tRNA requirement + Yeast 7.0 biomass equation
  1. P47095 impact could not be modeled as the Yeast 7.0 model contains no corresponding gene.