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Table 4 Pathway comparison between human candidate proteins and yeast orthologs using KEGG pathway annotations

From: A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

Human UniProt Ac Gene name Pathways Yeast UniProt Ac Yeast gene name Pathway match? Details
P13716 ALAD Porphyrin and clorophyll metabolism P05373 HEM2 Yes Same
   Biosynthesis of secondary metabolites    No Pathway only annotated in yeast; same substrate/product
P22830 FECH Porphyrin and clorophyll metabolism P16622 HEM15 Yes Same
   Biosynthesis of secondary metabolites    No Pathway only annotated in yeast; same substrate/product
P48637 GSS Glutathione metabolism Q08220 GSH2 Yes Same
P49247 RPIA Pentose phosphate pathway Q12189 RKI1 Yes Same
   Biosynthesis of secondary metabolites    No Pathway only annotated in yeast; same substrate/product
Q96GX9 APIP Cysteine and methionine metabolism P47095 MDE1 Yes Same
Q9Y2Z4 YARS2 Aminoacyl-tRNA biosynthesis P48527 MSY1 Yes Same
  1. This table summarizes the pathway involvement of the six identified candidate proteins. For all 6 proteins, the primary pathway involvement is the same, down to the same products and substrates and the same place within a pathway. For three of the yeast proteins, however, the pathway annotation in KEGG listed an additional pathway not annotated for humans: “Biosynthesis of secondary metabolites.” This is likely due to differential annotation between yeast and humans within KEGG. Because the substrates and products annotated for these pathways were identical to those of the primary pathways, these three proteins were not excluded and went onto analysis in the yeast FBA modeling.