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Table 2 Disease-related enrichment analysis of H. sapiens proteins involved in host-pathogen PPIs

From: Stringent homology-based prediction of H. sapiens-M. tuberculosis H37Rv protein-protein interactions

Gene list

Overlap

p-value

 (a)

Early Changers

32

1.022E-10

Late Changers

31

3.785E-14

Consistent Changers

35

1.500E-14

Early and Late Changers

56

6.996E-21

Early and Consistent Changers

49

3.721E-18

Consistent and Late Changers

42

1.499E-16

Macrophages and dendritic differentially expressed genes

107

2.097E-34

 (b)

Early Changers

6

3.08E-02

Late Changers

6

6.11E-03

Consistent Changers

8

1.04E-03

Early and Late Changers

10

2.94E-03

Early and Consistent Changers

9

4.30E-03

Consistent and Late Changers

9

1.07E-03

Macrophages and dendritic differentially expressed genes

35

5.23E-14

  1. This table summarizes H. sapiens proteins’ (involved in the predicted host-pathogen PPIs) enrichment (over-representation) in M. tuberculosis H37Rv infection and treatment-related differentially expressed gene lists.
  2. (a) is enrichment analysis results from the stringent homology-based approach.
  3. (b) is enrichment analysis results from the conventional homology-based approach.