Figure 1

Multiple sequence alignment of F12 proteins and family B DNAPs. Alignment blocks containing the conserved motifs implicated in the exonuclease and polymerase activities of the DNAPs are shown, with the catalytic amino acid positions marked with red bars. The conserved blocks are separated by numbers that indicate the lengths of poorly conserved sequence segments that are not shown (see Additional file 3 for full alignment). Each sequence is denoted by the species abbreviation and GenBank Identification (GI) number. Species abbreviations: Adoor, Adoxophyes orana granulovirus; Afrsw, African swine fever virus; Amsmo, Amsacta moorei entomopoxvirus ‘L’; Ascim, Ascobolus immersus; Bacph, Bacillus phage; Bovpa, Bovine papular stomatitis virus; Canox, Candida oxycetoniae; Canvi, Canarypox virus; Clapu, Claviceps purpurea; Cotvi, Cotia virus SPAn232; Deevi, Deerpox virus; Fowvi, Fowlpox virus; Glosp, Glomus sp. DAOM 229456; Helar, Helicoverpa armigera multiple nucleopolyhedrovirus; Humad, Human mastadenovirus B; Melsa, Melanoplus sanguinipes entomopoxvirus; Miccf, Microbotryum cf. violaceum BFL-2013; Myxvi, Myxoma virus; Neole, Neodiprion lecontei nucleopolyhedrovirus; Podan, Podospora anserina; Porpu, Porphyra purpurea; Rabfi, Rabbit fibroma virus; Rhiir, Rhizophagus irregularis DAOM 181602; Shevi, Sheeppox virus; Silvu, Silene vulgaris; Skuad, Skua adenovirus 1; Swivi, Swinepox virus; Vacvi, Vaccinia virus; Yabmo, Yaba monkey tumor virus; Yokpo, Yoka poxvirus.