Figure 1
From: Impairment of translation in neurons as a putative causative factor for autism
Distribution of the mean codon usage shift (S H _r) for 10,000 groups of generated mutations. Codon usage shift (SH) for observed synonymous mutations: 22.7, P(SH ≤ SH_r) = 0.007. Monte Carlo stimulation was used to estimate the significance of changes in codon usage, taking into account DNA context properties of mutations (see text for details). Codon frequencies for the brain-specific genes were estimated by Semon and co-workers [47].