Figure 1

Schematic of the model. An HIV-infected cell type (x_pre) that is susceptible to an antiretroviral targeting the step in the viral life cycle that proceeds at rate k_HIV after which the infected cell is no longer susceptible to the antiretroviral drug (x_post). The drug-susceptible cell can be inhibited at rate k_I to become an inhibited cell (x_I), which can progress no further in the HIV viral life cycle. This inhibition may be reversed at a rate k_-I. Cell types x_pre and x_I decay (e.g. through death of the cell or decay of the offending HIV virion) at rates δ_pre and δ_I, respectively.