Figure 3

Classification of the RAMPs. The tree-like scheme of RAMP relationships is based on the sequence similarity, structural features and neighborhood analysis described in the text, and should not be construed as a phylogenetic tree. Unresolved relationships are shown as multifurcations and tentative assignments are shown by broken lines. The catalytic activity of some of the RAMP proteins of the Cas5 and Cas7 groups involving the partially conserved histidines shown in the figure should be considered a tentative prediction.