Figure 1

A multiple sequence alignment of CREST proteins. Three predicted core transmembrane segments (labeled TM2, TM3 and TM7 respectively below the sequences) with conserved motifs are shown for representative sequences of eleven CREST groups. Putative active site residues are shown on black background, whereas mutations in these positions are on grey background. Non-charged residues in mainly hydrophobic positions are on yellow background. NCBI gene identification numbers, along with common names for some proteins, are shown before the species abbreviations. The numbers of residues in between the three segments are shown in parentheses. Starting/ending residue numbers and sequence lengths are shown in italic font and in brackets, respectively. Species abbreviations are as follows: At, Arabidopsis thaliana; Bs, Bacillus subtilis; Ca, Clostridium acetobutylicum; Ce, Caenorhabditis elegans; Cr, Chlamydomonas reinhardtii; Cs, Cyanothece sp.; Dd, Dictyostelium discoideum; Dm, Drosophila melanogaster; Fs, Frankia sp.; Hs, Homo sapiens; Mp, Micromonas sp.; Mr, Methylobacterium radiotolerans; Mt, Mycobacterium tuberculosis; Ol, Ostreococcus lucimarinus; Pp, Photobacterium profundum; Ps, Pseudovibrio sp.; Pt, Paramecium tetraurelia; Re, Ralstonia eutropha; Sc, Saccharomyces cerevisiae; Tb, Trypanosoma brucei; Tc, Tribolium castaneum. They are colored as follows: metazoans, black; fungi, brown; plants, green; protists, red; and bacteria, blue.