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Table 6 Nine genes highlighted as XLMR candidates by both the annotation and sequence motif method

From: A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis

HGNC symbol Description Location Function
FAM156A Family with sequence similarity 156, member A Xp11.23 Function Unknown
FAM156B Family with sequence similarity 156, member B Xp11.22 Function Unknown
UXT Ubiquitously-expressed transcript Xp11.23-p11.22 Plays a role in facilitating receptor-induced transcriptional activation [83]
TBL1X Transducin (beta)-like 1X-linked Xp22.3 Plays an essential role in transcription activation mediated by nuclear receptors [84]
MAGED4 Melanoma antigen family D, 4 Xp11 Mainly tumour cell proliferation [85]
MAGED4B Melanoma antigen family D, 4B Xp11 Mainly tumour cell proliferation [85]
ZC4H2 Zinc finger, C4H2 domain containing Xq11.1 Hepatocellular carcinoma-associated antigen [38]
APLN Apelin Xq25 Neuropeptide involved in the regulation of body fluid homeostasis and cardiovascular functions [86]
RAP2C Member of RAS oncogene family Xq25 Involved in serum response element mediated gene transcription [64]