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Table 5 Summary of data used to support actinobacterial ancestry of archaea.

From: The origin of a derived superkingdom: how a gram-positive bacterium crossed the desert to become an archaeon

Trait

Supports actinobacterial ancestry of Neomura

Supports actinobacterial Ancestry of Eukaryotes

Exclusive to Actinobacteria among Bacteria

20s proteasome

Yes

Yes

In a few other bacterial genomes

CCA added post-transcriptionally

No

No

Also in Firmicutes

Sterols

No

Yes

In a few other bacterial genomes (HGT), but only ones that could be vertical are actinobacterial

Chitin

No

No

Not in Actinobacteria

Serine/threonine signaling system

No

Yes

In Firmicutes too

Tyrosine Kinase

No

Yes

In many bacteria

H1 linker histone

No

Yes

In many bacteria

Calmodulin

No

Yes

In many bacteria

Phosphatidylinositol

No

Yes

Apparently unique to Actinobacteria, but related enzymes in other groups

Serine proteases

No

Yes

In many bacteria

Primary structure of α-amylase

No

No

In a few other bacterial genomes

Fatty Acid synthetase complex

No

Maybe

Exclusive to actinobacteria

Exospore formation

No

Yes

Exclusive to actinobacteria

HEH domain in Ku protein

No

No

Exclusive to actinobacteria

  1. Many of these traits argue for an actinobacterial role in eukaryogenesis but not the origin of archaea. This list of informative characters is taken from [16].