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Table 3 Protein folds most commonly found among non-homologous isofunctional enzymes

From: Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Fold EC1 EC2 EC3 EC4 EC5 EC6 Total
Total number of folds per EC class 46 39 87 34 36 2  
TIM beta/alpha-barrel 10 2 29 7 3 - 51*
NAD(P)-binding Rossmann-fold 20 - 5 2 1 - 28
Alpha/beta hydrolases 1 3 8 - - - 12*
Ribonuclease H-like motif - 3 9 - - - 12*
Metal-dependent phosphatases - - 11 - - - 11*
Alpha/alpha toroid - - 6 3 1 - 10*
Flavodoxin-like 4 1 4 1 - - 10
P-loop containing NTPases 1 7 - 1 - - 9
HAD-like - - 7 1 - - 8
Ferredoxin-like 3 3 - 1 1 - 8
  1. * - These folds are over-represented among the NISE (p < 0.05).
  2. EC1, oxidoreductases; EC2, transferases; EC3, hydrolases; EC4, lyases; EC5, isomerases; EC6, ligases.