Table 2 Enzymes with multiple structurally distinct, non-homologous isoforms
Enzyme name (EC) | Example (SwissProt) | Structure (PDB) | Fold names in SCOP (abbreviated) |
|---|---|---|---|
Acid phosphatase (EC 3.1.3.2) | PPA6_HUMAN | 1NDH | Phosphoglycerate mutase-like |
| Â | APHA_ECOLI | 1N8N | HAD-like |
| Â | PPA_ZYMMO | 1D2T | Acid phosphatases |
| Â | PPA5_HUMAN | 1UTE | Metallo-dependent phosphatases |
| Â | PPAC_HUMAN | 5PNT | Phosphotyrosine protein phosphatases I |
| Â | PHOA_PENCH | n/a | n/a |
Cellulase (EC 3.2.1.4) | GUNA_CLOCE | 1EDG | TIM beta/alpha-barrel |
| Â | GUNA_PSEFL | 1UT9 | Alpha/alpha toroid |
| Â | GUN1_STRHA | 2BOD | 7-Stranded beta/alpha barrel |
| Â | GUN_ASPAC | 1KS4 | Concanavalin A-like lectins/glucanases, |
| Â | GUNM_CLOTM | 2FVG | Phosphorylase/hydrolase-like |
| Â | GUNE_RUMFL | 1L0H | Predicted acyl carrier protein-like |
Superoxide dismutase (EC 1.15.1.1) | SODF_ECOLI | 1ISA | Fe,Mn superoxide dismutase (SOD) |
| Â | SODC_ECOLI | 1ESO | Immunoglobulin-like beta-sandwich |
| Â | SODN_STRSO | 1Q0D | Four-helical up-and-down bundle |
| Â | NEC1_NICLS | 2ET7 | Double-stranded beta-helix |
Phosphoprotein (Ser) phosphatase (EC 3.1.3.16) | PRP1_ECOLI | 1G5B | Metallo-dependent phosphatases |
| Â | PRPC_BACSU | 1TXO | PP2C-like |
| Â | CTDS1_HUMAN | 1TA0 | HAD-like |
| Â | DUS19_HUMAN | 1M3G | Phosphotyrosine protein phosphatases II |
Protein-tyrosine phosphatase (EC 3.1.3.48) | PTPA_STRCO | 1U2P | Phosphotyrosine protein phosphatases I-like |
| Â | PTPRD_HUMAN | 2FH7 | Phosphotyrosine protein phosphatases II |
| Â | MPIP3_HUMAN | 1QB0 | Rhodanese/Cell cycle control phosphatase |
| Â | YWQE_BACSU | 2ANU | Predicted 7-stranded beta/alpha barrel |
| Â | EYA3_MOUSE | 1JUD | Predicted HAD-like |
DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) | END3_ECOLI | 2ABK | DNA-glycosylase |
| Â | APEX1_HUMAN | 1E9N | DNase I-like |
| Â | APN1_YEAST | 1QTW | TIM beta/alpha-barrel |
| Â | FPG_ECOLI | 1K82 | MutM-like DNA repair proteins |
Adenylate cyclase (EC 4.6.1.1) | CYA1_HUMAN | 1CS4 | P-loop NTPases |
| Â | O69199_AERHY | 2ACA | CYTH-like phosphatases |
| Â | CYAA_BORPE | 1YRU | EF Hand-like |
| Â | CYAA_ECOLI | n/a | n/a |
Inorganic pyrophosphatase (EC 3.6.1.1) | IPYR_ARATH | 1TWL | OB-fold |
| Â | PPAC_BACSU | 1WPM | DHH phosphoesterases |
| Â | PPAX_BACSU | 2HDO | HAD-like |
| Â | AVP1_ARATH | n/a | Integral membrane protein, H + -transporting |
Catalase (EC 1.11.1.6) | CATA_HUMAN | 1QQW | Heme-dependent catalase-like |
| Â | CATA_ECOLI | 2FXG | Heme-dependent peroxidases |
| Â | MCAT_LACPL | 1JKU | Ferritin-like |
Peroxidase (EC 1.11.1.7) | PRDX6_MOUSE | 1PRX | Thioredoxin fold |
| Â | PERM_HUMAN | 1MYP | Heme-dependent peroxidases |
| Â | YCDB_ECOLI | 2d3q | Ferredoxin-like |
Chloride peroxidase (EC 1.11.1.10) | PRXC_PSEPY | 1A88 | Alpha/beta-hydrolases |
| Â | PRXC_CURIN | 1VNC | Acid phosphatase |
| Â | PRXC_CALFU | 2CPO | EF Hand-lik |
Peroxiredoxin (EC 1.11.1.15) | TDXH_AERPE | 2E2G | Thioredoxin fold |
| Â | AHPD_MYCTU | 1KNC | AhpD-like |
| Â | OSMC_ECOLI | 1NYE | OsmC-like |
Licheninase (EC 3.2.1.73) | GUB_NICPL | 2CYG | TIM beta/alpha-barrel |
| Â | GUB_BACSU | 1GBG | Concanavalin A-like lectins/glucanases, |
| Â | GUB_BACCI | 1V5C | Alpha/alpha toroid |