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Table 2 Enzymes with multiple structurally distinct, non-homologous isoforms

From: Non-homologous isofunctional enzymes: A systematic analysis of alternative solutions in enzyme evolution

Enzyme name (EC) Example (SwissProt) Structure (PDB) Fold names in SCOP (abbreviated)
Acid phosphatase (EC 3.1.3.2) PPA6_HUMAN 1NDH Phosphoglycerate mutase-like
  APHA_ECOLI 1N8N HAD-like
  PPA_ZYMMO 1D2T Acid phosphatases
  PPA5_HUMAN 1UTE Metallo-dependent phosphatases
  PPAC_HUMAN 5PNT Phosphotyrosine protein phosphatases I
  PHOA_PENCH n/a n/a
Cellulase
(EC 3.2.1.4)
GUNA_CLOCE 1EDG TIM beta/alpha-barrel
  GUNA_PSEFL 1UT9 Alpha/alpha toroid
  GUN1_STRHA 2BOD 7-Stranded beta/alpha barrel
  GUN_ASPAC 1KS4 Concanavalin A-like lectins/glucanases,
  GUNM_CLOTM 2FVG Phosphorylase/hydrolase-like
  GUNE_RUMFL 1L0H Predicted acyl carrier protein-like
Superoxide dismutase
(EC 1.15.1.1)
SODF_ECOLI 1ISA Fe,Mn superoxide dismutase (SOD)
  SODC_ECOLI 1ESO Immunoglobulin-like beta-sandwich
  SODN_STRSO 1Q0D Four-helical up-and-down bundle
  NEC1_NICLS 2ET7 Double-stranded beta-helix
Phosphoprotein (Ser) phosphatase
(EC 3.1.3.16)
PRP1_ECOLI 1G5B Metallo-dependent phosphatases
  PRPC_BACSU 1TXO PP2C-like
  CTDS1_HUMAN 1TA0 HAD-like
  DUS19_HUMAN 1M3G Phosphotyrosine protein phosphatases II
Protein-tyrosine phosphatase
(EC 3.1.3.48)
PTPA_STRCO 1U2P Phosphotyrosine protein phosphatases I-like
  PTPRD_HUMAN 2FH7 Phosphotyrosine protein phosphatases II
  MPIP3_HUMAN 1QB0 Rhodanese/Cell cycle control phosphatase
  YWQE_BACSU 2ANU Predicted 7-stranded beta/alpha barrel
  EYA3_MOUSE 1JUD Predicted HAD-like
DNA-(apurinic or apyrimidinic site) lyase (EC 4.2.99.18) END3_ECOLI 2ABK DNA-glycosylase
  APEX1_HUMAN 1E9N DNase I-like
  APN1_YEAST 1QTW TIM beta/alpha-barrel
  FPG_ECOLI 1K82 MutM-like DNA repair proteins
Adenylate cyclase (EC 4.6.1.1) CYA1_HUMAN 1CS4 P-loop NTPases
  O69199_AERHY 2ACA CYTH-like phosphatases
  CYAA_BORPE 1YRU EF Hand-like
  CYAA_ECOLI n/a n/a
Inorganic pyrophosphatase (EC 3.6.1.1) IPYR_ARATH 1TWL OB-fold
  PPAC_BACSU 1WPM DHH phosphoesterases
  PPAX_BACSU 2HDO HAD-like
  AVP1_ARATH n/a Integral membrane protein, H + -transporting
Catalase
(EC 1.11.1.6)
CATA_HUMAN 1QQW Heme-dependent catalase-like
  CATA_ECOLI 2FXG Heme-dependent peroxidases
  MCAT_LACPL 1JKU Ferritin-like
Peroxidase
(EC 1.11.1.7)
PRDX6_MOUSE 1PRX Thioredoxin fold
  PERM_HUMAN 1MYP Heme-dependent peroxidases
  YCDB_ECOLI 2d3q Ferredoxin-like
Chloride peroxidase (EC 1.11.1.10) PRXC_PSEPY 1A88 Alpha/beta-hydrolases
  PRXC_CURIN 1VNC Acid phosphatase
  PRXC_CALFU 2CPO EF Hand-lik
Peroxiredoxin
(EC 1.11.1.15)
TDXH_AERPE 2E2G Thioredoxin fold
  AHPD_MYCTU 1KNC AhpD-like
  OSMC_ECOLI 1NYE OsmC-like
Licheninase
(EC 3.2.1.73)
GUB_NICPL 2CYG TIM beta/alpha-barrel
  GUB_BACSU 1GBG Concanavalin A-like lectins/glucanases,
  GUB_BACCI 1V5C Alpha/alpha toroid