Figure 12

Morphology and phenotypic distribution of tumor treated with 2DG followed by chemotherapy at step 72. Morphology and phenotypic distribution of tumor treated with 2DG followed by chemotherapy at step 72. A represents chemoresistance (red resistant and green sensitive), B hyperglycolysis (red high glycolysis and green low), C shows acid resistance (red resistance to low pHe and green sensitivity) and D shows quiescent cells (green) and proliferative (yellow). The "pulverized" morphology grants a higher surface-to-volume ratio what increases efficiency of chemotherapy. All resistant cells have been removed during treatment by energy depletion.