Figure 5

Curves for the different growth signals. Because the ROS level S is a function of C _t , the proliferation and death signals mediated by S can be given as a function of either S (as in (a)) or of C _t (as in (b)). Attenuation of proliferation by crowding (the -σP) is disregarded here because it affects the proliferation signal in a way that depends on the instantaneous prostate mass. (a) Prostate cell growth and death signals due to ROS as a function of S. (b) Prostate cell growth and death signals due to ROS given as a function of C _t , as S is itself a function of C _t . (c) Proliferation and death signal due to the effective AR:ligand concentration, C _t . (d) Overall proliferation and death signals mediated by both ROS and AR:ligand concentration. Because ROS level is a function of the AR:ligand concentration, C _t , the overall signal can be given as a function of only C _t .