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Table 2 Set of 100 essential COGs conserved in 99% of bacteria

From: Massive comparative genomic analysis reveals convergent evolution of specialized bacteria

COG

Code

COG's description

COG0563

F

Adenylate kinase and related kinases

COG0528

F

Uridylate kinase

COG0587

L

DNA polymerase III, alpha subunit

COG2812

L

DNA polymerase III, gamma/tau subunits

COG0592

L

DNA polymerase sliding clamp subunit (PCNA homolog)

COG0358

L

DNA primase (bacterial type)

COG0084

L

Mg-dependent DNase

COG0305

L

Replicative DNA helicase

COG0629

L

Single-stranded DNA-binding protein

COG0188

L

Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

COG0187

L

Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

COG0202

K

DNA-directed RNA polymerase, alpha subunit/40 kD subunit

COG0086

K

DNA-directed RNA polymerase, beta' subunit/160 kD subunit

COG0568

K

DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32)

COG0571

K

dsRNA-specific ribonuclease

COG0250

K

Transcription antiterminator

COG0195

K

Transcription elongation factor

COG0081

J

Ribosomal protein L1

COG0244

J

Ribosomal protein L10

COG0080

J

Ribosomal protein L11

COG0102

J

Ribosomal protein L13

COG0093

J

Ribosomal protein L14

COG0200

J

Ribosomal protein L15

COG0197

J

Ribosomal protein L16/L10E

COG0203

J

Ribosomal protein L17

COG0256

J

Ribosomal protein L18

COG0335

J

Ribosomal protein L19

COG0090

J

Ribosomal protein L2

COG0292

J

Ribosomal protein L20

COG0091

J

Ribosomal protein L22

COG0089

J

Ribosomal protein L23

COG0198

J

Ribosomal protein L24

COG0211

J

Ribosomal protein L27

COG0087

J

Ribosomal protein L3

COG0254

J

Ribosomal protein L31

COG0088

J

Ribosomal protein L4

COG0094

J

Ribosomal protein L5

COG0097

J

Ribosomal protein L6P/L9E

COG0222

J

Ribosomal protein L7/L12

COG0051

J

Ribosomal protein S10

COG0100

J

Ribosomal protein S11

COG0048

J

Ribosomal protein S12

COG0099

J

Ribosomal protein S13

COG0184

J

Ribosomal protein S15P/S13E

COG0228

J

Ribosomal protein S16

COG0186

J

Ribosomal protein S17

COG0238

J

Ribosomal protein S18

COG0052

J

Ribosomal protein S2

COG0268

J

Ribosomal protein S20

COG0092

J

Ribosomal protein S3

COG0522

J

Ribosomal protein S4 and related proteins

COG0098

J

Ribosomal protein S5

COG0360

J

Ribosomal protein S6

COG0049

J

Ribosomal protein S7

COG0096

J

Ribosomal protein S8

COG0103

J

Ribosomal protein S9

COG0233

J

Ribosome recycling factor

COG0858

J

Ribosome-binding factor A

COG0013

J

Alanyl-tRNA synthetase

COG0018

J

Arginyl-tRNA synthetase

COG0215

J

Cysteinyl-tRNA synthetase

COG0008

J

Glutamyl- and glutaminyl-tRNA synthetases

COG0124

J

Histidyl-tRNA synthetase

COG0060

J

Isoleucyl-tRNA synthetase

COG0495

J

Leucyl-tRNA synthetase

COG0143

J

Methionyl-tRNA synthetase

COG0016

J

Phenylalanyl-tRNA synthetase alpha subunit

COG0072

J

Phenylalanyl-tRNA synthetase beta subunit

COG0193

J

Peptidyl-tRNA hydrolase

COG0442

J

Prolyl-tRNA synthetase

COG0172

J

Seryl-tRNA synthetase

COG0441

J

Threonyl-tRNA synthetase

COG0180

J

Tryptophanyl-tRNA synthetase

COG0162

J

Tyrosyl-tRNA synthetase

COG0024

J

Methionine aminopeptidase

COG0336

J

tRNA-(guanine-N1)-methyltransferase

COG0030

J

Dimethyladenosine transferase (rRNA methylation)

COG0012

J

Predicted GTPase, probable translation factor

COG0216

J

Protein chain release factor A

COG0050

J

GTPases – translation elongation factors

COG0231

J

Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A)

COG0264

J

Translation elongation factor Ts

COG0480

J

Translation elongation factors (GTPases)

COG0361

J

Translation initiation factor 1 (IF-1)

COG0532

J

Translation initiation factor 2 (IF-2; GTPase)

COG0290

J

Translation initiation factor 3 (IF-3)

COG0465

O

ATP-dependent Zn proteases

COG0484

O

DnaJ-class molecular chaperone with C-terminal Zn finger domain

COG0533

O

Metal-dependent proteases with possible chaperone activity

COG0443

O

Molecular chaperone

COG0576

O

Molecular chaperone GrpE (heat shock protein)

COG0691

O

tmRNA-binding protein

COG0653

U

Preprotein translocase subunit SecA (ATPase, RNA helicase)

COG0201

U

Preprotein translocase subunit SecY

COG0706

U

Preprotein translocase subunit YidC

COG0481

M

Membrane GTPase LepA

COG0275

M

Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

COG0536

R

Predicted GTPase

COG1160

R

Predicted GTPases

COG0319

R

Predicted metal-dependent hydrolase