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Archived Comments for: Are we degenerate tetraploids? More genomes, new facts

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  1. octaploids

    Herman Van Eck, Wageningen University, Netherlands

    16 December 2008

    Two rounds of genome duplication would generate from diploids -> tetraploids and from tetraploids -> octaploids. <br><br>So I do not understand the title of the paper. <br><br>In fact there is a paper on this issue that indeed refers to octaploidy.<br>TJ Gibson and J Spring (2000) Evidence in favour of ancient octaploidy in the vertebrate genome, Biochem Soc Trans 28:259–264.

    Competing interests

    None declared

  2. 1R or 2R

    Amir Abbasi, National Center for Bioinformatics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan

    22 December 2008

    Among the "Whole genome duplication" scenario proponents there are two versions of Ohno,s hypothesis, some has suggested two round (2R) scenario (leading to octaploids), whereas others only one round (1R) of whole genome duplication (leading to tetraploids, please see Ref 25 of this manuscript, and also see Gu et al 2002 Nat.Genet.31, 205-209 and Durand Dannie TRENDS in Genetics Vol.19 No1 Jan 2003). The title of the manuscript refers to 1R. However in the text I provide a critical overview of 2R also (please see in particular the sections “Paralogy regions in the Human genome” and “HOX cluster duplication and the history of vertebrate genome evolution”. I can hope this comment will let the readers to understand the title of this manuscript. <br><br>I am the author of this manuscript. <br>

    Competing interests

    No competing interest