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Table 4 Hotspots non-randomly associated with non-synonymous sites in tumor suppressor genes according to the NSB test

From: Mutational hotspots in the TP53gene and, possibly, other tumor suppressors evolve by positive selection

Gene

Total number of codons

Number of non-synonymous hotspots

TP53

394

59

BRCA1

1864

12

BRCA2

3419

27

p16

157

1

  1. The hotspots are listed in Additional file 3
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Biology Direct

ISSN: 1745-6150

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