Figure 3

^aV gene germline sequence aligned with Fab gene sequence in the vicinity of codon deletions. Dashes indicate identity with the germline-encoded sequence. Asterisk (*) indicate deleted bases. ^bThe 4 codon deletion in the CDR3 region of the 023.3H11 heavy chain is shown compared to a clonally related sequence that lacks the deletion. Bases constituting RGYW/WRCY motifs are underlined. Codons are numbered as in[24]. IGMT/HUGO nomenclature for the kappa light chain names listed above is IGKV4-1 (B3) and IGKV3-20 (A27).