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Table 3 Positive selection pressure in Treated and Untreated datasets

From: Distinguishing HIV-1 drug resistance, accessory, and viral fitness mutations using conditional selection pressure analysis of treated versus untreated patient samples

 

Selection pressure

Conditional selection pressure

Treated

+a

+

-

+a

+

Not + selected, or not present

Untreated

+

-b

+

+

Not + selected, or not present

+

Codon

12,13,19,33,35,37,41,57,60,62,63,6477,93 71c

10,24,30,54,73,74,82,90 53d

None

19, 63, 71 93e

10, 24, 30, 35, 48, 54, 73, 82, 88, 90

None

  1. a positively selected. For selection pressure, K a /K s > 1 and LOD > 2; for conditional selection pressure, (K a /K s )Y|Xa > 1, (K a /K s )Y|X > 1, LOD > 3 and p < 0.001.
  2. b negatively selected (K a /K s < 1 and LOD > 2)
  3. c codon 71 is positively selected in Treated samples (K a /K s > 1 and LOD > 2), and it has a K a /K s value greater than 1 but a LOD score less than 2 in Untreated samples.
  4. d codon 53 is positively selected in Treated samples (K a /K s > 1 and LOD > 2), and it has a K a /K s value less than 1 but a LOD score less than 2 in Untreated samples.
  5. e In Treated dataset, codon 93 is positively selected with (K a /K s )Y|Xa > 1, (K a /K s )Y|X > 1, LOD > 3 but p > 0.001.
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Biology Direct

ISSN: 1745-6150

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