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Section edited by Tal Dagan and Martijn Huynen

The genomics section embraces studies of whole genome structure, function and evolution. This includes the genomic research of specific life forms as well as metaorganisms and particular habitats. Papers considered for publication include methodology contributions dealing with the sequencing, assembly and annotation of genomic data, studies of whole genome or metagenome composition, organization and function, as well as evolutionary genomics.

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  1. Surveying deleterious variation in human populations is crucial for our understanding, diagnosis and potential treatment of human genetic pathologies. A number of recent genome-wide analyses focused on the pre...

    Authors: Michael S Breen and Fyodor A Kondrashov

    Citation: Biology Direct 2010 5:68

    Content type: Research

    Published on:

  2. It is difficult to measure precisely the phenotypic complexity of living organisms. Here we propose a method to calculate the minimal amount of genomic information needed to construct organism (effective infor...

    Authors: Yun Jiang and Cunshuan Xu

    Citation: Biology Direct 2010 5:59

    Content type: Research

    Published on:

  3. The mutation spectra of the TP53 gene and other tumor suppressors contain multiple hotspots, i.e., sites of non-random, frequent mutation in tumors and/or the germline. The origin of the hotspots remains unclear,...

    Authors: Galina V Glazko, Vladimir N Babenko, Eugene V Koonin and Igor B Rogozin

    Citation: Biology Direct 2006 1:4

    Content type: Research

    Published on:

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