Skip to main content
Fig. 3 | Biology Direct

Fig. 3

From: Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models

Fig. 3

Inhibition of TRAF6 suppressed pyroptosis in AP rat models. (A) Ultrastructure of pancreatic acinar cells from AP rats was observed under transmission electron microscope; N: nuclear, M: mitochondrion, Z: zymogen granules, ER: Endoplasmic reticulum. (B) The expression of GSDMD in the pancreatic tissue of AP rats was detected by immunofluorescent staining (400×). (C) Pyroptotic cells in the pancreatic tissue of AP rats were detected by TUNEL staining (200×). D, E) The levels of TLR9, TRAF6, NLRP3, and pyroptosis-relaxed proteins in the pancreatic tissue of AP rats were determined by RT-qPCR and Western blot. F) The expression of GSDMD in pancreatic tissue of AP rats was detected by immunohistochemistry staining (200×). *P < 0.05, **P < 0.01 and ***P < 0.001

Back to article page