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Fig. 2 | Biology Direct

Fig. 2

From: Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models

Fig. 2

Inhibition of TRAF6 attenuated the severity of AP in rat models. (A) Schematic illustration of the process of establishment of HTG-AP rat model and administration of MG-132. (B) Serum TG levels in control and HTG rats were measured. (C) Different concentrations of MG-132 (2.5, 5, and 10 mg/kg) were injected intraperitoneally in rats 0.5 h before modeling. Rats were sacrificed at 24 h after the last injection of cerulein and the histopathologic score was assessed (HE staining 200×). (D) Rats were treated with 10 mg/kg MG-132 and sacrificed at 24 and 48 h. The histopathologic score was assessed (HE staining 200×). (E) Serum amylase levels in AP rats were measured. (F) Serum IL-1β levels in AP rats were measured by ELISA. *P < 0.05, **P < 0.01 and ***P < 0.001

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