Fig. 2From: Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat modelsInhibition of TRAF6 attenuated the severity of AP in rat models. (A) Schematic illustration of the process of establishment of HTG-AP rat model and administration of MG-132. (B) Serum TG levels in control and HTG rats were measured. (C) Different concentrations of MG-132 (2.5, 5, and 10 mg/kg) were injected intraperitoneally in rats 0.5 h before modeling. Rats were sacrificed at 24 h after the last injection of cerulein and the histopathologic score was assessed (HE staining 200×). (D) Rats were treated with 10 mg/kg MG-132 and sacrificed at 24 and 48 h. The histopathologic score was assessed (HE staining 200×). (E) Serum amylase levels in AP rats were measured. (F) Serum IL-1β levels in AP rats were measured by ELISA. *P < 0.05, **P < 0.01 and ***P < 0.001Back to article page