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Fig. 1 | Biology Direct

Fig. 1

From: Combined treatment of nerve growth factor and transcranical direct current stimulations to improve outcome in children with vegetative state after out-of-hospital cardiac arrest

Fig. 1

Perfusion SPECT images before and after combined treatment with hr-NGF and tDCS. (a)99mTc-HMPAO SPECT images (transaxial slices) of the first patient, before the combined treatment, showed a moderate reduction in radiotracer uptake (hypoperfusion) in the left frontal and temporal cortices, as well as in the left caudate nucleus, left putamen and right thalamus. (b) After the combined treatment, a mild increase in 99mTc-HMPAO uptake was detected in the left frontal cortex (+ 10%), left temporal cortex (+ 9%), left caudate nucleus (+ 17%), left putamen (+ 13%) and right thalamus (+ 12%). (c) 99mTc-HMPAO SPECT images (transaxial slices) of the second patient, before the combined treatment with hr-NGF and tDCS, showed a moderate-to-severe reduction in radiotracer uptake (hypoperfusion) in the right and left frontal cortices, right and left parietal cortices, left occipital cortex, caudate nucleus, putamen and thalamus, bilaterally. (d) After the combined treatment, a slight increase in radiotracer uptake was detected in the right frontal cortex (+ 6%), left parieto-occipital cortex (+ 8%) and cerebellum (+ 11%). (e) In the third patient, 99mTc-HMPAO SPECT images (transaxial slices), before the combined treatment with hr-NGF and tDCS, showed a mild reduction in radiotracer uptake (hypoperfusion) in the right and left frontal cortices, right parietal cortex, right and left temporal poles, in the thalami and cerebellar hemispheres. (f) After the combined treatment, a slight increase in radiotracer uptake was detected in the right and left frontal cortices (7+% and + 8%, respectively), right parietal cortex (+ 7%), right temporal pole (+ 11%) and cerebellum (+ 7%) (b)

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