Fig. 5
From: Probing pathways by which rhynchophylline modifies sleep using spatial transcriptomics
RHY modifies the brain transcriptome in a brain region-dependent manner
(A) DEGs of regions of interest representing white matter tracts (WMT), cerebral cortex, basolateral amygdala (BLA), hippocampus, thalamus, lateral hypothalamus (LH) and dorsal, medial and ventromedial hypothalamus (DMVH). Bulk (full slice) data are also included for comparison. Only DEGs (FDR < 0.05) found in more than one comparison for at least one brain region are shown. Circle size indicates the significance level, hot colors indicate increase, and cold colors decrease.
(B) Gene ontology enriched terms extracted from the DAVID annotation online tool for DEGs of the different brain regions. The number of DEGs enriched for the term category is indicated only for significant terms. The hypothalamus analysis includes LH and DMVH.