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Table 5 Frequency of T lymphocytes expressing PD-1 and IFN-γ in spleen and peritoneal ascitic fluid of C57BL/6 mice transplanted with #40a MM cells

From: Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo

Cells

Spleen

Ascites

Control

Bor

p value

Control

Bor

p value

CD4+PD-1+

16.2 ± 2.7

9.9 ± 2.1

p ≤ 0.01

29.9 ± 6.0

28.6 ± 8.2

ns

CD4+IFN-γ+

4.8 ± 1.3

3.8 ± 0.4

ns

14.3 ± 3.3

28.2 ± 8.7

p ≤ 0.01

CD8+PD-1+

2.1 ± 0.5

1.3 ± 0.3

p ≤ 0.05

20.6 ± 3.6

14.8 ± 3.4

p ≤ 0.05

CD8+IFN-γ+

18.2 ± 3.6

16.9 ± 1.4

ns

34.4 ± 13.3

54.2 ± 5.3

p ≤ 0.01

  1. ns not significant
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Biology Direct

ISSN: 1745-6150

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