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Table 3 Frequency of immune cells in spleen and peritoneal ascitic fluid of mice transplanted with syngeneic #40a MM cells

From: Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo

Cells

Spleen

Ascites

Control

Bor

p value

Control

Bor

p value

CD4+

18.8 ± 3.7

19.6 ± 3.8

ns

13.8 ± 2.7

5.1 ± 2.4

p ≤ 0.001

CD8+

18.0 ± 3.2

18.6 ± 2.1

ns

14.4 ± 1.1

12.8 ± 6.1

ns

B

30.4 ± 5.0

23.9 ± 3.0

p ≤ 0.05

22.2 ± 5.5

17.7 ± 2.1

ns

MDSC

56.6 ± 18.0

70.2 ± 5.2

ns

26.6 ± 8.8

22.1 ± 9.6

ns

TAM

3.6 ± 3.7

1.2 ± 0.3

ns

13.0 ± 2.9

11.8 ± 2.1

ns

  1. B B cells, MDSC myeloid-derived suppressor cells, TAM tumor-associated macrophages, ns not significant
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