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Fig. 6 | Biology Direct

Fig. 6

From: Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo

Fig. 6

Effects of Bor on the expression EGFR and ErbB2 and activation of downstream signaling effectors. a Western blotting analysis was performed on human and mouse MM cell lines treated with 25 nM Bor or DMSO for 48 h. Actin was used as a loading control. b–h Densitometric ratios between EGFR and Actin (b), ErbB2 and Actin (c), pERK1 and ERK (d), pERK2 and ERK (e), pAKT and AKT (f), p-p38 and p38. g The ratios were calculated following densitometric analysis of the bands from two independent experiments and expressed as mean ± SD values (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001)

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