Fig. 1

Neuronal diversity is recovered using only synaptic genes. t-SNE embedding visualization of the dataset from Tasic et al. [13] using the most variable genes among A all genes in the dataset, B only synaptic genes annotated in SynGO, C only presynaptic genes or D only postsynaptic genes, allow distinction of the annotated cell types to a similar extent. Dotted lines indicate cell classes and colors correspond to cell types described in Tasic et al. [13]. Quantification was performed by calculating the cell class (E) and cell type (F) discriminatory power of each gene set in the MetaNeighbor pipeline. Wilcoxon rank test was used to determine statistically different performance of each pair of gene sets (*: p <  = 0.05; **: p <  = 0.01; ***: p <  = 0.001; ****: p <  = 0.0001)