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Fig. 1 | Biology Direct

Fig. 1

From: circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway

Fig. 1

circACTR2 is decreased in GEM-resistant PC cells

A Scatter plot shows the up-regulated and down-regulated circRNAs in acquired GEM-resistant SW1990/GZ PC cells compared with parental SW1990 cells. B The differentially expressed circRNAs with most change fold in SW1990/GZ PC cells compared with SW1990 cells were validated by qRT-PCR. C Relative cell viability of a panel of PC cell lines treated with increased concentration of gemcitabine for 72 h was determined by CCK-8 assay. D circACTR2 expression was determined in a panel of PC cell lines by qRT-PCR assay. E Gene Ontology analysis and F pathway analysis of circACTR2 based on microarray profile data. *P < 0.05 and **P < 0.01 vs. SW1990/GZ; #P < 0.05 and ##P < 0.01 vs. Panc-1

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