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Fig. 5 | Biology Direct

Fig. 5

From: Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression

Fig. 5

Disruption of MAM formation and mitochondrial remodeling in MS mice cardiomyocytes. A The mitochondria-associated endoplasmic reticulum membrane (MAM) was examined using TEM assay. ER, blue color, endoplasmic reticulum; m, red, color, mitochondria; ER-P, reticulophagy; MAM, red arrow. B MAM proteins mitochondrial antiviral signaling (MAVS) and mitofusin 2 (MFN2) expression and colocalization were examined by immunostaining and confocal microscopy. C, D The mitochondrial morphological remodeling was measured and quantified using TEM analysis. E, F Mitochondrial distribution and damage score quantification by TEM analysis

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