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Fig. 4 | Biology Direct

Fig. 4

From: Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression

Fig. 4

Lipid accumulation in cardiovascular tissue regulated by CAV-1 in vivo. A The immunostaining was used to identify lipid droplet transport from the cardiovascular to the myocardium mediated by endothelial cell`s CAV-1. Red color, CAV-1; green color, lipid, blue color DAPI, yellow color CAV-1/lipid colocalization. EC, endothelial cell; CM, cardiomyocyte; V, vascular. B, C The oil-Red O staining was used to confirm and quantify of lipid droplets accumulation in cardiac tissue. Data are presented as the mean ± SEM; ****P < 0.0001. D The lipid droplets accumulation in cardiomyocyte, intramitochondrial, extravascular cardiomyocyte and cardiac macrophages were examined by TEM assay. LD, lipid droplet; L, lysosome

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Biology Direct

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