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Fig. 7 | Biology Direct

Fig. 7

From: Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis

Fig. 7

LINC00326 modulates tumor progression and DKK2 expression by interacting with miR-657 in NSCLC cells. A549 and NCI-H1650 cells were transfected with miR-657 mimics and either OE-LINC00326 or OE-LINC00326 along with sh-DKK2. a DKK2 protein levels, shown by western blotting. b Quantification of different protein expression levels, **P < 0.01 compared with miR-657 mimics transfection group; ##P < 0.01 compared with miR-657 mimics + LINC00326 overexpression plasmids co-transfection group. c Cell viability at 24, 48, and 72 h. d, e Apoptosis measured by flow cytometry, **P < 0.01 compared with miR-657 mimics transfection group; #P < 0.05 compared with miR-657 mimics + LINC00326 overexpression plasmids co-transfection group. f Protein levels of Wnt1, Wnt3A, and β-catenin in transfected cells, shown by western blotting with GAPDH as the loading control. Data are presented as mean ± standard deviation. **P < 0.01

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