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Fig. 4 | Biology Direct

Fig. 4

From: Upregulation of long intergenic non-coding RNA LINC00326 inhibits non-small cell lung carcinoma progression by blocking Wnt/β-catenin pathway through modulating the miR-657/dickkopf WNT signaling pathway inhibitor 2 axis

Fig. 4

miR-657 stimulates proliferation and reduces promotes apoptosis in A549 and HCC827 cells. a Transfection efficiencies of the miR-657 mimic and inhibitor in A549 and HCC827 cells, shown by RT-qPCR. b, c Proliferation of transfected A549 and HCC827 cells, measured by CCK-8 and EdU assays. d Apoptosis in transfected A549 and HCC827 cells, evaluated by flow cytometry. e Levels of Wnt1, Wnt3A, and β-catenin proteins in transfected A549 and HCC827 cells (CTRL, mimic-NC, miR-657 mimics, inhibitor NC, and miR-657 inhibitor groups), shown by western blotting. Data are presented as mean ± standard deviation. The experiments were repeated three times. *P < 0.05; **P < 0.01; ***P < 0.001

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