Fig. 3

The risk model of five cuproptosis-related gene in TCGA training and validation cohorts. A, E In the TCGA training and testing cohort, the risk score distribution and median value are shown. B, F The dot plot depicted the TCGA training and testing cohort’s survival status, survival time, and risk score distributions. C, G In the TCGA training and testing cohort, a heatmap shows the patients were divided into high- and low-risk groups according to the risk factor of five cuproptosis-related gene expression. D, H In the TCGA training and testing cohort, Kaplan–Meier showed the survival of patients in high- and low-risk groups. I–M The results of survival analysis in TCGA-LIHC revealed that the high expression of CLEC3B, HPN, and SLC25A28 suggested longer survival periods. Higher levels of RNFT1 and PDXK expression, on the other hand, suggested a shorter survival time. N For 1-, 3-, and 5-year overall survival, the AUC of the survival ROC curves was utilized to assess the predictive efficacy of the developed risk signature