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Fig. 5 | Biology Direct

Fig. 5

From: p53 regulates expression of nuclear envelope components in cancer cells

Fig. 5

Expression of Nuclear Lamina (NL) and Nuclear Pore Complex (NPC) components is altered in PDAC and predicts prognosis. A Heatmap showing proteomic data of normal adjacent tissue (NAT, n = 67 patients) and pancreatic ductal adenocarcinoma (PDAC, n = 140 patients) for members of NL (top) and NPC (bottom); data are expressed as z-score. B protein (top) and RNA (bottom) levels between NAT (N, n = 67 patients) and PDAC (P, n = 140 patients) for selected members of NL and NPC; data are expressed as z-score by box and whiskers plot. ***p-value < 0.001; ****p-value < 0.0001. C RNA expression for selected members of NL and NPC according to TP53 status (wild-type, Wt; mutant, Mut); data are expressed as log2 RSEM-UQ by box and whiskers plot. *p-value < 0.05; **p-value < 0.01. D RNA expression of the selected members of NL and NPC in PDAC samples stratified by tumour weight (≤ 3.5 cm n = 80 patients, or > 3.5 cm n = 58 patients); dot plot data (z-score) are presented by mean (red line) ± SEM. *p-value < 0.05. From A to D source data is cBioPortal [8] and Cao et al. [7]. E overall survival of pancreatic cancer patients stratified for LMNB1 mRNA levels. F disease free survival of pancreatic cancer patients stratified for LMNB1, LMNB2, and NUP107 mRNA levels; in E and F source data is GEPIA2 (high level cohort = 89 patients; low level cohort = 89 patients)

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