Fig. 4

p53-Lamin B1-NPC dependent genes alterations in cancer. A Heatmap of ATAC and RNAseq data showing the most significant genes derived from figure 3B; data are presented as shrunken log2 fold change (FC, shp53/shCTR). B ATACseq signal (Upper panel) and RNAseq signal (lower panel) variation between KP CTR and KP shp53 for the indicated genes; the signal is expressed in sequencing reads; data are presented as mean (red line in upper panel; bar in lower panel) ± SEM. Dots represents biological replicates (n = 2 or n = 3); *p-value < 0.05; **p-value < 0.01; ****p-value < 0.0001. C Histogram bars showing the most recurrent mutated genes from A in a pancreatic cancer dataset,source: cBioPortal [8]; the genetic alteration (amplification, deletion, or mutation) frequency is expressed as percentage with respect to the cohort (308 patients)