Fig. 1
From: p53 regulates expression of nuclear envelope components in cancer cells
Source: TargetGeneRegulation database [16]
p53 transcriptionally controls the expression of nuclear envelope components. A and B RNA sequencing data of nuclear pore (A) and nuclear lamina (B). The heatmap (left) and the box plot (right) show z-score and fold change (KP shp53/KP CTR) values, respectively; the orange dotted line indicates the threshold for genes upregulated or downregulated. #1–3 are biological replicates. C–E, comprehensive view of p53 direct regulation on human and mouse nuclear envelope genes. CDKN1A and PLK1 are positive controls for activation and repression by p53, respectively.