Fig. 10
From: CXCL1 promotes colon cancer progression through activation of NF-κB/P300 signaling pathway
CXCL1 activates the NF-κB pathway via P300. a–d CXCL1 activated NF-κB signaling in MC38 colon cancer cells, presenting as increased expression levels of p-IκBα/IκBα, nuclear-p65/p65. e CXCL1 overexpression in MC38 colon cancer cells promoted P300 mRNA expression. f, g C646 treatment significantly inhibited the nuclear-p65 expression. h, i mRNA expression levels of CXCL1 and IL6 decreased after C646 treatment of MC38CXCL1+/+ cells, and the decreased level of IL6 remained consistent with CXCL1. ns no significant, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001